Correlation of microvessel density with histopathological parameters of carcinoma breast
Referat
Background & objectives: Microvessel density (MVD) is a surrogate measure of tumour angiogenesis,
and is well known for over two decades to identify individuals with a high risk of recurrence with greater
prevision than traditional markers. This study aims to assess the utility of MVD and its correlation with
the Nottingham Prognostic Index (NPI) and other routine histopathological parameters in carcinoma
breast.
Methods: This two year retrospective, cross-sectional and analytical study evaluated 143 women
with breast cancer presenting to rural tertiary hospital in central India. These women were graded
histopathologically, the immunophenotype was determined using ER (estrogen receptor), PR
(progesterone receptor), Her2 neu (human epidermal growth factor receptor 2 neu) and Ki-67
proliferation index (Kiel-67) immunohistochemical markers and anti-CD34 antibody to stain the
endothelial cell clusters displaying the microvessels. The NPI was generated for each participant based
on the tumour size, histologic grade and involvement of lymph node. The parameters were compared
with the CD34 scores. Differential and inferential statistics, including the independent t test, analysis of
variance, Pearson’s correlation coefficient, Spearman’s rank correlation coefficient and point biserial
correlation coefficient, were used for statistical analysis.
Results: This study showed that CD34 values ranged from 6-36 microvessels/hpf, with 24.16±6.77
microvessels/hpf as the mean. The mean microvessel counts showed a significant positive correlation
with the Bloom–Richardson histological grade, vascular invasion, LN (lymph node) positivity and NPI.
However, there was no significant correlation of CD34 values with the participant’s age, tumour size
neither any significant association of CD34 values with the individual’s immunophenotype.
Interpretations & conclusions: A positive linear correlation of the microvessel counts and the NPI scores
suggest that with an increase in tumour angiogenesis, there was increased proliferative potential. Based
on the significant correlation between the microvessel counts and the vascular invasion of the tumour
masses in this study, it can be assumed that there will be vascular invasion if the microvessel count is
higher and vice-versa. Although it is established that angiogenesis and neovascularization are required
for the expansion of the solid tumour tissue, the heterogeneous nature of this entity makes it difficult for
obtaining a linear correlation. Hence, it is suggested t
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