Expression of CD105 but not of E-cadherin is associated with malignancy recurrence and disease-free interval in laryngeal cancer in men
Аннотация
Introduction. In this study we analyzed CD105 (endoglin) and E-cadherin expression in laryngeal squamous cell
carcinoma (LSCC) to evaluate their clinicopathologic significance.
Material and methods. Expression of CD105 and E-cadherin was examined immunohistochemically using paraffin-
-embedded archival tissues of 72 (35 glottic and 37 supraglottic) previously untreated LSCC male patients. The mean
value of the positively-stained microvessels for CD105 counted in four hot spots for each case was used as the final
intratumoralmicrovessel density (MVD). A staining score of E-cadherin was calculated based on the percentage of
cells stained (0–100%).
Results. MVD was significantly higher in patients with advanced TNM stage (P = 0.004) and younger than 65 (P =
0.008). Nodal metastases were more frequent in the cases with low E-cadherin expression (P = 0.000). Tumor recurrence
was associated with advanced TNM stage (P = 0.035) and high MVD (P = 0.002). A high MVD was an independent
predictor of malignancy recurrence (P = 0.021). The log-rank test showed a significant difference in the disease-free
interval in patients stratified according to the MVD value (P = 0.016). Spearman’s rank correlation test did not show
a significant correlation between E-cadherin and CD105 expression.
Conclusions. CD105-assessed MVD and expression of E-cadherin are promising prognostic factors for the outcome
of patients with LSCC. Increased expression of CD105 could help predict patients with an increased risk of developing
loco-regional recurrence after surgical treatment. Decreased E-cadherin expression is a potential predictor of lymph
node metastases. (Folia Histochemica et Cytobiologica 2023, Vol. 61, No. 3, 183–192)
Об авторах
Список литературы
Alimkhodjaeva L. T., Kh N. M. RELEVANCE OF DIAGNOSTICS AND TREATMENT OF BREAST CANCER IN MEN. – 2021.
Норбекова М. Х. Прогностическое и предиктивное значение ангиогенеза при раке грудной железы. – 2021.
Kurbankulov U. M. et al. Study of morphological and clinical bases of organpreserving surgery for ampular cancer of the rectum. – 2023.
Alimkhodjaeva L. T. et al. Diagnostic Significance of Molecular Genetic Markers in the Prognosis of the Breast Cancer Clinical Course. – 2019.
Alimkhodjaeva L. T., Norbekova M. H. Clinical significance of the density of tumor microvessels in breast cancer in men. – 2022.
Kh N. M., Zievedenova S. S. TUMOR LYMPHOCYTES IN HER2-POSITIVE BREAST CANCER (Litera review) //Original medicine. – 2023. – Т. 2. – №. 2.
Эргашева Ш. Т. Бухгалтерский учет //Учебное пособие «Иктисод-молия. – 2010.
Tuychieva O., Sh E. Оrganizational activity as a function of management of the learning process //Актуальные проблемы гуманитарных и естественных наук. – 2016. – №. 3-5. – С. 67-69.
Эргашева Ш. Т. Взаимосвязи системы бухгалтерского и налогового учета. – 2016.
Khalmuratova M. T. PROFESSIONAL LANGUAGE OF DENTIST-DENTISTRY //Экономика и социум. – 2018. – №. 10 (53). – С. 40-42.
Алимходжаева Л. Т. Иммуноморфологические изменения в опухолях молочной железы при неоадъювантной химиотерапии в условиях искусственной гипергликемии //Опухоли женской репродуктивной системы. – 2008. – №. 2. – С. 35-37.
Alimkhodjaeva L. T., Kh N. M. RELEVANCE OF DIAGNOSTICS AND TREATMENT OF BREAST CANCER IN MEN. – 2021.
ZAKIROVA L. T., TelmanovnaALIMKHODJAEVA L., KADYROVA D. A. Chromosomal Disorders and Aberrant DNA Methylation as Early Biomarkers of Breast Cancer Risk in Young Women //Journal of Life Science and Biomedicine. – 2018. – Т. 8. – №. 1. – С. 01-05.
Алимходжаева Л. Т. Диагностическое значение изучения уровней про-и противовоспалительных цитокинов иммунной системы у больных раком молочной железы //Опухоли женской репродуктивной системы. – 2009. – №. 3-4. – С. 49-52.
Алимходжаева Л. Т. Диагностическое значение изучения уровней про-и противовоспалительных цитокинов иммунной системы у больных раком молочной железы //Опухоли женской репродуктивной системы. – 2009. – №. 3-4. – С. 49-52.
Как цитировать
Copyright (c) 2024 Ilm scienceweb
Это произведение доступно по лицензии Creative Commons «Attribution-NonCommercial-NoDerivatives» («Атрибуция — Некоммерческое использование — Без производных произведений») 4.0 Всемирная.