Ten-Year Survival of Breast Cancer in Iran: A National Study (Retrospective Cohort Study)
Abstract
Abstract
Purpose: This study aimed to estimate the 5- and 10-year
survival rates of breast cancer in Iran. Methods: This retrospective cohort study was performed in 2019 on breast cancer patients registered in the national cancer registry system
of Iran during 2007–2014. The patients were contacted to
collect their information and status (alive or dead). Age and
pathological type of tumor were categorized into five
groups, and the place of residence was divided into 13 regions. The Kaplan-Meier method and the Cox proportional
hazards model were used for data analysis. Results: A total
of 87,902 patients were diagnosed with breast cancer during
the study, 22,307 of whom were followed-up. The 5- and 10-
year survival rates of the patients were 80% and 69%, respectively. The mean age of the patients was 50.68 ± 12.76 years
(median age, 49 years). About 2.3% of the patients were
male. The 5- and 10-year survival rates were 69% and 50% in
men, respectively. The highest survival rate was reported in
the age group of 40–49 years, and the lowest rate was found
in the age group of ≥70 years. Of all pathological types, 88%
were found in the invasive ductal carcinoma group; the highest survival rate was reported in the noninvasive carcinoma
group. The highest survival rate was reported in the Tehran
region and the lowest in the Hamedan region. Based on the
results, the Cox proportional hazards model, sex, age group,
and pathological type were statistically significant differences. Conclusion: This nationwide study performed on breast
cancer patients indicated an improvement in the overall survival rate of these patients over the past years (the 5-year
survival rate increased from 71% in 2011 to 80% in the present study), which might be attributed to advances in cancer
management. © 2022 S. Karger AG, Basel
Introduction
Breast cancer (BC) is the most common cancer in
women worldwide, although it occurs in both sexes. In
2020, it was identified as the fifth cause of cancer death in
both sexes and the leading cause of mortality due to cancer in women worldwide [1]. Nevertheless, the prognosis
of BC is more favorable than that of other common malignancies. In Iran, BC isthe most common type of cancer
in women (and also in both sexes), with an age-standardized incidence rate of 32.63/105
in 2015 [2]. It is also the
fifth and first cause of cancer death in both sexes and females, respectively [3].
There has been an increasing trend in the incidence of
BC in recent years [4]. In a nationwide study performed
in Iran in 2011, the 5-year survival rate of BC was estimated at 71% [5]. In this study, data was collected from
About the Authors
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